Polymorphism of IL10RA (S159G) Associated with Late-Onset Ulcerative Colitis
作者: DhivyaAnandSrilakshmiprabhaSangeethaVenkateshBalachandar
作者单位: 1Department of Human Genetics and Molecular Biology , Bharathiar University , Coimbatore 641 046 , Tamil Nadu , India
2Institute of Surgical Gastroenterology, Rajiv Gandhi Government General Hospital, Madras Medical College , Chennai , Tamil Nadu , India
3Department of Surgical Gastroenterology , Government Mohan Kumaramangalam Medical College , Salem , Tamil Nadu , India
4Vellalar College for Women , Thindal, Erode 638 012 , Tamil Nadu , India
刊名: International Journal of Human Genetics, 2016, Vol.16 (3-4), pp.128-131
来源数据库: Taylor & Francis Journal
DOI: 10.1080/09723757.2016.11886288
原始语种摘要: Abstract(#br)Inflammatory bowel disease (IBD) is a group of disorders distinguished as Crohn’s Disease (CD) and Ulcerative colitis (UC). The etiology is multi-factorial and numerous genes are involved in the pathogenesis of IBD; hence the genetic cause is only moderately understood. Interleukin-10, a candidate gene of UC is activated by binding of IL10RA and IL10RB. The objective of the study is to examine IL10RA polymorphism in two patients with late onset of UC with an increased risk for development of Colorectal Cancer (CRC). Case 1 is a 35-year old male presented with UC for past 6 months who underwent colonoscopy which showed inflammatory ulcers, inflammation and pseudopolyps. Case 2 is a 37-year old female undergoing UC treatment for past 6-7 years and the colonoscopy revealed...
全文获取路径: Taylor & Francis  (合作)

  • colonoscopy 结肠镜检查
  • examine 
  • numerous 许多的
  • genetic 遗传的
  • moderately 适度地
  • polymorphism 多晶形
  • involved 涉及
  • objective 接物镜
  • female 女性的
  • increased 增加