Genomics of Type 2 Diabetes Mellitus and Glycemic Traits
作者: Vipin GuptaGagandeep Kaur Walia
作者单位: 1Department of Anthropology , University of Delhi , Delhi 110 007 , India
2Public Health Foundation of India , Gurgaon , Haryana , India
刊名: International Journal of Human Genetics, 2017, Vol.17 (3), pp.140-144
来源数据库: Taylor & Francis Journal
DOI: 10.1080/09723757.2017.1383655
关键词: Genome-wide Association StudyType 2 DiabetesIndiaGlycemic Traits
原始语种摘要: ABSTRACT(#br)The increased burden of type 2 diabetes mellitus (T2DM) has accelerated the number of genetic studies in different human populations for detecting at least predictive biomarkers related to T2DM. Genome-wide association designs have successfully identified number of potential genetic variants associated with T2DM and explained the polygenic nature of T2DM inheritance using large sample sizes. Genetic epidemiologists have also explored the quantitative glycemic traits simultaneously with T2DM and provided comprehensive picture of overlapping findings through biological pathways. Indian studies on genetics of T2DM are generally limited to the candidate gene based association designs and efforts were primarily made to validate the European findings. This manuscript is a broad...
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关键词翻译
关键词翻译
  • genetic 遗传的
  • India 印度
  • quantitative 量的
  • simultaneously 同时地
  • manuscript 原稿
  • inheritance 继承
  • findings 结论
  • polygenic 复成的
  • potential 
  • different 不相同的