Two Independent Genetic Origins of β<sup>+</sup>- Thalassemia Due to -31 A to G Mutation in Thai and Japanese Populations
作者: LertthamFucharoen YamsriFucharoen
作者单位: 1Medical Science Program, Graduate School, Khon Kaen University , Thailand
2Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University , Khon Kaen , Thailand
刊名: International Journal of Human Genetics, 2015, Vol.15 (4), pp.191-198
来源数据库: Taylor & Francis Journal
DOI: 10.1080/09723757.2015.11886267
原始语种摘要: Abstract(#br)Haplotype associated with the -31 (A-G) β+ -thalassemia gene in seven Thai individuals were examined and compared with that described originally in Japanese. Seven polymorphic restriction sites within β-globin gene cluster were determined using allele specific polymerase chain reaction (ASPCR) methods newly developed for rapid β+-globin haplotyping. A concordant result of DNA polymorphisms examined using ASPCR and conventional PCR-restriction fragment length polymorphism (PCR-RFLP) method was observed. It was found that all these seven Thai β+-thalassemia alleles were associated with the β-globin haplotype (+ - - - - - +), which is different from that described for a Japanese subject (- + + - + + -). This indicates two independent origins. As...
全文获取路径: Taylor & Francis  (合作)

  • globin 珠朊
  • Japanese 日本人日语日本的
  • sup 吃晚饭
  • restriction 限制
  • allele 等位基因
  • observed 观察到的
  • seven 
  • genetic 遗传的
  • thalassemia 地中海贫血
  • haplotype 单倍体型