The Effect of TGFB1 and CD14 Gene Polymorphisms on the Clinical Findings of Cystic Fibrosis in Turkish Patients
作者: TemurhanTamayGurkanAkgulOzcekerKekikCagatayAydinGuler
作者单位: 1Department of Medical Biology , Istanbul Faculty of Medicine, Istanbul University , Istanbul , Turkey 34080
2Department of Pediatrics , Pediatric Allergy Unit, Istanbul Faculty of Medicine, Istanbul University , Istanbul , Turkey
3Department of Medical Genetics , Medical Faculty, Trakya University , Edirne , Turkey
4Department of Biostatistics , Istanbul Faculty of Medicine, Istanbul University , Istanbul , Turkey
刊名: International Journal of Human Genetics, 2016, Vol.16 (1-2), pp.40-47
来源数据库: Taylor & Francis Journal
DOI: 10.1080/09723757.2016.11886276
原始语种摘要: Abstract(#br)Significant effects of several modifying genes on the clinical features of cystic fibrosis (CF) have been reported. In the present study, the researchers investigated the effects of transforming growth factor beta 1 (TGFB1) and cluster of differentiation 14 (CD14) polymorphisms on the clinical status of patients with CF. The present study included sixty-five patients with CF and eighty five healthy controls with no pulmonary disease. Single-nucleotide polymorphisms in the TGFB1 gene (rs1800469, rs1800470, rs8179181) were studied using DNA sequence analyses; the CD14 gene polymorphism rs2569190 was evaluated using restriction fragment length polymorphism analysis. The frequency of rs1800469 (TT genotype) was significantly higher in the healthy controls than in the patients...
全文获取路径: Taylor & Francis  (合作)
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关键词翻译
关键词翻译
  • nucleotide 核苷酸
  • modifying 修改
  • several 各自
  • confirmed 已确认的
  • polymorphism 多晶形
  • effect 效应
  • restriction 限制
  • length 距离
  • growth 生长
  • fragment 碎屑