Gender-specific Association of ATP2B1 ( rs2681472 ) Gene Polymorphism with Essential Hypertension in South Indian Population
作者: Vijayashree Priyadharsini JayaseelanKarthikeyan MuthusamyShridevi VenkatramaniParamasivam ArumugamJayaraman GopalswamySanthiya Sathiyavedu Thiagarajan
作者单位: 1Department of Genetics, Dr. ALM PGIBMS , University of Madras , Taramani, Chennai , Tamil Nadu , India
2Department of Bioinformatics , Alagappa University , Karaikudi 630 004 , Tamil Nadu , India
3IIIT-Hyderabad , Gachibowli, Hyderabad , Telangana 500 032 , India
4Centre for Cellular and Molecular Biology , Hyderabad 500 007 , Telangana , India
刊名: International Journal of Human Genetics, 2017, Vol.17 (4), pp.169-176
来源数据库: Taylor & Francis Journal
DOI: 10.1080/09723757.2017.1421431
关键词: Essential HypertensionATP2B1Calcium SignalingSNPPCR-RFLP
原始语种摘要: ABSTRACT(#br)Essential hypertension (EH) makes up ∼ 95 percent of all hypertensive cases and has no clear identifiable cause. Although EH has a strong genetic basis, identification of genes associated with it has been difficult because of the complexity of regulation of blood pressure, its multifactorial nature, and the presence of multiple susceptibility genes. The present case–control association study investigates the possible involvement of the ATP2B1 (rs2681472) polymorphism in EH patients. The study group included 568 hypertensive cases and 604 normotensive controls, whose DNA were genotyped by the PCR-RFLP method. A significant association was observed between the T allele (p = 0.038) and the TT genotype (p = 0.051) with EH. Gender-wise segregation evidenced a significant...
全文获取路径: Taylor & Francis  (合作)
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关键词翻译
关键词翻译
  • Page Control Register 女性的
  • hypertensive 高血压的
  • normotensive 血压正常的
  • Association 美国公共卫生协会
  • hypertension 高血压
  • controls 控制机构
  • association 联合
  • susceptibility 磁化率
  • female 女性的
  • PCR 女性的
  • RFLP 限制片长多态性