Erythrocyte cAMP in Determining Frequency of Acute Pain Episodes in Sickle Cell Disease Patients from Odisha State, India
作者: Bimal P. JitPradeep K. MohantyAvinash PradhanPrasanta PurohitKishalaya DasSiris PatelSatyabrata MeherShalini SinhaJyoti R. MohantyRajendra Kumar BeheraPadmalaya Das
作者单位: 1School of Life Sciences , AIPH University , Bhubaneswar , Odisha State , India
2;Sickle Cell Clinic and Molecular Biology Laboratory , Veer Surendra Sai Institute of Medical Sciences and Research , Burla, Sambalpur , Odisha State , India
3;School of Life Sciences , Sambalpur University , Jyoti Vihar, Burla , Sambalpur , Odisha State , India
4;Department of Medicine , Veer Surendra Sai Institute of Medical Sciences and Research , Burla, Sambalpur , Odisha State , India
5;Central Institute of Freshwater Aquaculture , Bhubaneswar , Odisha State , India
6;Multidisciplinary Research Unit , Maharaja Krishna Chandra Gajapati Medical College , Berhampur , Odisha State , India
刊名: Hemoglobin, 2019, Vol.43 (2), pp.88-94
来源数据库: Taylor & Francis Journal
DOI: 10.1080/03630269.2019.1623248
关键词: Acute pain episodesCyclic adenosine monophosphate (cAMP)EpinephrineSickle cell diseaseVaso-occlusive crisis (VOC)
原始语种摘要: Abstract(#br)Vaso-occlusive crisis (VOC) occurs more frequently during stress in sickle cell disease patients. Epinephrine released during stress increases adhesion of sickled red blood cells (RBCs) to endothelium and to leukocytes, a process mediated through erythrocyte cyclic adenosine monophosphate (cAMP). Increased adhesion of sickled RBCs retards blood flow through the capillaries and promotes vaso-occlusion. Therefore, we examined the association of RBC-cAMP levels with frequency of acute pain episodes in sickle cell disease subjects. Using a case control study design, we measured RBC-cAMP levels, fetal hemoglobin (Hb F), α-thalassemia (α-thal) and other hematological parameters at baseline (sham treated) and after stimulation with epinephrine. The cases consisted of sickle cell...
全文获取路径: Taylor & Francis  (合作)
影响因子:0.894 (2012)

  • Sickle 轩辕八至十三
  • cAMP 环腺苷酸
  • sickle 切割器镰刀
  • occlusive 闭合的
  • epinephrine 肾上腺素
  • India 印度
  • treated 加工的
  • monophosphate 单磷体
  • occlusion 锢囚
  • hematological 血液学的