Cytogenetic Analysis and Screening of ApoE and Neurotransmitters in Alzheimer’s Patients in Tamil Nadu Population
作者: SasikalaaSureshKumarBalamuralikrishnanaArunaKarthickkumarAhmadSankarDhivyaSrilakshmiprabhaDeviBalachandar
作者单位: 1Department of Zoology , Bharathiar University , Coimbatore 641 046 , Tamil Nadu , India
2Department of Human Genetics and Molecular Biology , Bharathiar University , Coimbatore 641 046 , Tamil Nadu , India
刊名: International Journal of Human Genetics, 2016, Vol.16 (3-4), pp.107-115
来源数据库: Taylor & Francis Journal
DOI: 10.1080/09723757.2016.11886285
原始语种摘要: Abstract(#br)Alzheimer’s disease (AD) is the leading neurodegenerative disorder and the cause of dementia in the elderly people. The current research investigated the relevance of AD individuals challenged with copper exposure and the disease onset through cytogenetic and molecular analysis. The research was performed on 70 AD patients categorized into two groups as the early-onset with age below 65 (n=31) and the late-onset aged above 65 (n=39). The chromosomal aberrations (CAs) were examined in both the groups showing higher CAs in the late-onset and the anomalies were seen in the chromosomes 10q, 9p, 9q, 14p and 19q in 21 patients and the micronucleus (MN) assay was also found to be higher in the late-onset patients. Assessment of ApoE gene showed a definite significant difference...
全文获取路径: Taylor & Francis  (合作)

  • onset 开始
  • serotonin 血清素
  • dementia 痴呆
  • dopamine 多巴胺
  • micronucleus 小核
  • exposure 暴露
  • biochemical 生物化学的
  • higher 
  • elderly 上了年纪的
  • believe 认为