Autoantibodies in Pandemrix®-induced narcolepsy: Nine candidate autoantigens fail the conformational autoantibody test
作者: Madeleine WalleniusAlexander LindOmar AkelEmma KarlssonMarkus SvenssonElin ArvidssonAnita RameliusCarina TörnLars PalmÅke LernmarkHelena Elding Larsson
作者单位: 1Department of Clinical Sciences Malmö , Lund University/CRC, Skåne University Hospital SUS , Malmö , Sweden
2;Section for Paediatric Neurology, Department of Paediatrics , Skåne University Hospital SUS , Malmö , Sweden
刊名: Autoimmunity, 2019, Vol.52 (4), pp.185-191
来源数据库: Taylor & Francis Journal
DOI: 10.1080/08916934.2019.1643843
关键词: AutoantibodiesNarcolepsy type 1Pandemrix®-vaccinationHypocretin/orexinAutoimmunity
原始语种摘要: Abstract(#br)Study objectives:(#br) Narcolepsy type 1 (NT1) is a chronic sleep disorder characterized by loss of hypocretin-producing neurons. Increased NT1 incidence was observed in Sweden following mass-vaccination with Pandemrix®. Genetic association to HLA DQB1*06:02 implies an autoimmune origin, but target autoantigen remains unknown. Candidate autoantigens for NT1 have previously been identified in solid-phase immunoassays, while autoantibodies against conformation-dependent epitopes are better detected in radiobinding assays. The aims are to determine autoantibody levels against nine candidate autoantigens representing (1) proteins of the hypocretin transmitter system; Preprohypocretin (ppHypocretin), Hypocretin peptides 1 and 2 (HCRT1 and HCRT2) and Hypocretin receptor 2 (HCRTR2);...
全文获取路径: Taylor & Francis  (合作)
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影响因子:2.767 (2012)

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关键词翻译
关键词翻译
  • autoantibody 自身抗体
  • candidate 选择物
  • narcolepsy 发自睡病
  • conformational 构造的
  • autoantigen 自身抗原
  • vaccination 注射疫苗
  • induced 感应的
  • previously 以前
  • transcription 地名转写
  • remains 残渣