Association of VDR gene polymorphisms with risk of relapsing-remitting multiple sclerosis in an Iranian Kurdish population
| 作者： | Rasoul Abdollahzadeh, Parisa Moradi Pordanjani, Farideh Rahmani, Fatemeh Mashayekhi, Asaad Azarnezhad, Yaser Mansoori |
| 作者单位： |
1Noncommunicable Diseases Research Center , Fasa University of Medical Sciences , Fasa , Iran 2Department of Medical Genetics , School of Medicine , Tehran University of Medical Sciences , Tehran , Iran 3Department of Biology , Faculty of Science , Alzahra University , Tehran , Iran 4Department of Medical Biotechnology , School of Medicine , Hamedan University of Medical Sciences , Hamedan , Iran 5Department of Cell & Molecular Biology , School of Biology , College of Science , University of Tehran , Tehran , Iran 6Cellular and Molecular Research Center , Kurdistan University of Medical Sciences , Sanandaj , Iran |
| 刊名： | International Journal of Neuroscience, 2018, Vol.128 (6), pp.505-511 |
| 来源数据库： | Taylor & Francis Journal |
| DOI： | 10.1080/00207454.2017.1398158 |
| 关键词： | Multiple sclerosis; Single nucleotide polymorphism; Association study; Vitamin D receptor; Kurdish population; |
| 原始语种摘要： | ABSTRACT(#br)Purpose:(#br) The purpose of this study was to evaluate the association of VDR Apa-I, Bsm-I, Fok-I, Taq-I single nucleotide polymorphisms (SNPs) with multiple sclerosis (MS) risk in an Iranian Kurdish population.(#br)Materials and methods:(#br) A population including of 118 patients and 124 healthy matched controls were recruited to the study. Genotyping of the SNPs was accomplished using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).(#br)Results:(#br) The frequency of allele T of Fok-I ( P = 0.003) and allele C of Taq-I ( P = 0.0003) was significantly different between case and control subjects and showed significant association with risk of MS (OR = 1.84, 95% CI = 1.23–2.76; OR = 1.98, 95% CI = 1.36–2.87, respectively). CT genotype (OR = 1.7,... |
