Association of VDR gene polymorphisms with risk of relapsing-remitting multiple sclerosis in an Iranian Kurdish population
作者: Rasoul AbdollahzadehParisa Moradi PordanjaniFarideh RahmaniFatemeh MashayekhiAsaad AzarnezhadYaser Mansoori
作者单位: 1Noncommunicable Diseases Research Center , Fasa University of Medical Sciences , Fasa , Iran
2Department of Medical Genetics , School of Medicine , Tehran University of Medical Sciences , Tehran , Iran
3Department of Biology , Faculty of Science , Alzahra University , Tehran , Iran
4Department of Medical Biotechnology , School of Medicine , Hamedan University of Medical Sciences , Hamedan , Iran
5Department of Cell & Molecular Biology , School of Biology , College of Science , University of Tehran , Tehran , Iran
6Cellular and Molecular Research Center , Kurdistan University of Medical Sciences , Sanandaj , Iran
刊名: International Journal of Neuroscience, 2018, Vol.128 (6), pp.505-511
来源数据库: Taylor & Francis Journal
DOI: 10.1080/00207454.2017.1398158
关键词: Multiple sclerosisSingle nucleotide polymorphismAssociation studyVitamin D receptorKurdish population
原始语种摘要: ABSTRACT(#br)Purpose:(#br) The purpose of this study was to evaluate the association of VDR Apa-I, Bsm-I, Fok-I, Taq-I single nucleotide polymorphisms (SNPs) with multiple sclerosis (MS) risk in an Iranian Kurdish population.(#br)Materials and methods:(#br) A population including of 118 patients and 124 healthy matched controls were recruited to the study. Genotyping of the SNPs was accomplished using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).(#br)Results:(#br) The frequency of allele T of Fok-I ( P = 0.003) and allele C of Taq-I ( P = 0.0003) was significantly different between case and control subjects and showed significant association with risk of MS (OR = 1.84, 95% CI = 1.23–2.76; OR = 1.98, 95% CI = 1.36–2.87, respectively). CT genotype (OR = 1.7,...
全文获取路径: Taylor & Francis  (合作)
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影响因子:1.216 (2012)

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关键词翻译
关键词翻译
  • nucleotide 核苷酸
  • population 母体
  • sclerosis 硬化
  • VDR Validated Data Record
  • Association 美国公共卫生协会
  • observed 观察到的
  • remitting 减轻
  • association 联合
  • evaluate 求...的值
  • genetic 遗传的