The effects of lycopene on intestinal injury due to methotrexate in rats
作者: Yusuf YucelSuzan TaburOrhan GozeneliSezen KocarslanAhmet SekerHasan BuyukaslanEmin ŞavikAlpay AktumenAbdullah OzgonulAli UzunkoyNurten Aksoy
作者单位: 1Department of General Surgery, Medical Faculty , Harran University , 63100 Sanliurfa , Turkey
2Division of Endocrinology, Department of Internal Medicine , Gaziantep University Faculty of Medicine , Turkey
3Department of Pathology, Medical Faculty , Harran University , 63100 Sanliurfa , Turkey
4Emergency Department, Medical Faculty , Harran University , 63100 Sanliurfa , Turkey
5Department of Clinical Biochemistry, Faculty of Medicine , Harran University , 63100 Sanliurfa , Turkey
6Department of Pathology, Medical Faculty , Karabuk University , Karabuk , Turkey
刊名: Redox Report, 2016, Vol.21 (3), pp.113-118
来源数据库: Taylor & Francis Journal
DOI: 10.1179/1351000215Y.0000000041
关键词: LycopeneIntestinal injuryMethotrexateTNF-αIL-1βOxidative stress
原始语种摘要: Objective(#br): The aim of this study was to investigate the effects of lycopene (Lyc) on methotrexate (Mtx)-induced intestinal damage in rats.(#br)Method(#br): Twenty-eight male Sprague Dawley rats were divided into four equal groups: control, Mtx, Lyc, and Mtx-L.(#br)Control group(#br): Rats were given only the vehicle.(#br)Lyc group(#br): Rats were given Lyc (10 mg/kg) with corn oil by oral gavage for 10 days.(#br)Mtx group(#br): Rats were injected intraperitoneally with a single dose of 20 mg/kg of Mtx and given corn oil by oral gavage.(#br)Mtx-L group(#br): Rats were treated with Lyc (10 mg/kg) for 10 days after a single dose of Mtx (20 mg/kg). All of the rats were euthanized using terminal anesthesia, and the intestinal tissues were removed for histological examination and for...
全文获取路径: Taylor & Francis  (合作)

  • intestinal 肠的
  • methotrexate 氨甲喋呤
  • lycopene 番茄烯
  • intestine 
  • cytokine 细胞因子
  • increased 增加
  • oxidative 氧化的
  • gavage 管饲法
  • injury 损害
  • anesthesia 感觉缺失