The effect of intrauterine growth on leukocyte telomere length at birth
作者: Alketa StefaAgaristi LamprokostopoulouDespina D. BrianaAnna KontogeorgouIfigeneia PapageorgiouAriadne Malamitsi-PuchnerOurania TsitsilonisSarantis GagosEvangelia Charmandari
作者单位: 1Division of Endocrinology and Metabolism , Biomedical Research Foundation of the Academy of Athens , Athens , Greece
2;Department of Neonatology , National and Kapodistrian University of Athens Medical School, Aretaieion University Hospital , Athens , Greece
3;Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics , National and Kapodistrian University of Athens Medical School, “Aghia Sophia” Children’s Hospital , Athens , Greece
4;Department of Animal and Human Physiology, Faculty of Biology , University of Athens , Athens , Greece
5;Division of Genetics , Center of Experimental Medicine and Translational Research, Biomedical Research Foundation of the Academy of Athens , Athens , Greece
刊名: The Journal of Maternal-Fetal & Neonatal Medicine, 2019, Vol.32 (23), pp.3948-3953
来源数据库: Taylor & Francis Journal
DOI: 10.1080/14767058.2018.1479392
关键词: Appropriate-for-gestational-age neonatesDevelopmental origins of health and diseaseIntrauterine growth restrictionLarge-for-gestational-age neonates
原始语种摘要: Abstract(#br)Objective:(#br) Telomeres are specialized nucleoprotein structures located at the ends of chromosomes, which play a crucial role in genomic stability. Telomere shortening has been proposed as a biomarker for the onset of age-related diseases. This study aimed to determine whether restricted or increased intrauterine growth affects leukocyte telomere length (LTL) at birth.(#br)Materials and methods:(#br) One hundred sixty-five ( n = 165) full-term neonates participated in the study. Fetuses were classified as intrauterine growth restriction (IUGR, n = 21), large-for-gestational-age (LGA, n = 15), or appropriate-for-gestational-age (AGA, n = 129), based on customized birth-weight standards. Mixed arteriovenous cord blood samples were collected for isolation of leukocyte DNA....
全文获取路径: Taylor & Francis  (合作)
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关键词翻译
关键词翻译
  • intrauterine 子宫内的
  • restriction 限制
  • gestational 妊娠期的
  • birth 出生
  • growth 生长
  • leukocyte 白血球
  • telomere 端粒
  • length 距离
  • differ 不同
  • circumference 圆周