Effect of ADRB2 (adrenergic receptor β 2) gene polymorphisms on the occurrence of asthma and on the response to nebulized salbutamol in South Indian patients with bronchial asthma
作者: Neel Jayesh ShahSaka Vinod KumarUmamaheswaran GurusamyArun Kumar Annan SudarsanDeepak Gopal Shewade
作者单位: 1Department of Pharmacology and
2Department of Pulmonary Medicine , Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) , Pondicherry , India
刊名: Journal of Asthma, 2015, Vol.52 (8), pp.755-762
来源数据库: Taylor & Francis Journal
DOI: 10.3109/02770903.2015.1012589
原始语种摘要: Abstract(#br) Introduction : Genetic mutations in the β2 receptor could alter its functioning and the response to β2 agonists. The study was done to find out the effect of two commonly occurring polymorphisms-Arg16Gly and Gln27Glu, on cause of asthma and on response to nebulized salbutamol in South Indian subjects of asthma. Methods : After baseline measurements of Forced Expiratory Volume in 1st second (FEV1), Forced Vital Capacity (FVC) and Peak Expiratory Flow Rate (PEFR), five mg of nebulized salbutamol was administered and spirometry was repeated. The increase in these parameters was calculated and patients were included for genotyping if the percentage increase in FEV1 was ≥12%. The frequencies of these polymorphisms in patients were...
全文获取路径: Taylor & Francis  (合作)
影响因子:1.848 (2012)

  • asthma 哮喘
  • salbutamol 沙丁胺醇
  • bronchial 支气管的
  • increased 增加
  • occurrence 事件
  • spirometry 肺量测定法
  • associated 相关的
  • receptor 接受体
  • haplotype 单倍体型
  • adrenergic 肾上腺素性的