Crystal structure and protective effect in osteoarthritis of Co(II)-mediated pyridinium-bearing coordination polymer
作者: Wei HeQinghui YuanHaibo Zeng
作者单位: 1Department of Pain Management , Mianyang Central Hospital , Mianyang , Sichuan , China
2;Department of Pathology , Mianyang Central Hospital , Mianyang , Sichuan , China
3;Department of Anesthesiology, the Central Hospital of Wuhan, Tongji Medical College , Huazhong University of Science and Technology , Wuhan , Hubei , China
刊名: Journal of Coordination Chemistry, 2019, Vol.72 (22-24), pp.3471-3480
来源数据库: Taylor & Francis Journal
DOI: 10.1080/00958972.2019.1700234
关键词: Coordination polymerPyridinium-bearing ligandCo(II)-complexOsteoarthritisMolecular docking
原始语种摘要: Abstract(#br)By using a mixed-ligand approach, a new Co(II)-mediated pyridinium-bearing coordination polymer, {[Co(BCbpe)(ipa)]·3H2O}n (1(#br)), has been prepared by reaction of Co(NO3)2·6H2O) and isophthalic acid (H2ipa) in the presence of pyridinium chloride 1-(4-carboxybenzyl)4-[2-(4-pyridyl)-vinyl] (HBCbpeCl) in EtOH/H2O (V:V = 1:1). Furthermore, a green hand grinding technique has been implemented to reduce the particle size of 1(#br) to generate nanosheets of 1(#br) with good water dispersivity. The post-traumatic osteoarthritis (OA) model was constructed and the in vivo protective effect of nano 1(#br) was evaluated. First, the inflammatory level of OA rats was measured by ELISA detection. Second, for...
全文获取路径: Taylor & Francis  (合作)
影响因子:1.801 (2012)

  • pyridinium 吡啶盐
  • II Interactive Interface
  • polymer 聚合物
  • coordination 配位
  • docking 靠泊
  • osteoarthritis 骨关节炎
  • pyridyl 氮苯基
  • bearing 方位
  • effect 效应
  • structure 构造