Synthesis, structure and antitumor activity of the binuclear tetranitrosyl iron complex with 2-mercaptobenzthiazole – the nitric oxide donor (NO)
作者: Tatiana N. RudnevaOlga S. ZhukovaGennady V. ShilovIrina O. ChikilevaMichael V. KisilevskiiNataliya A. SaninaSergey M. Aldoshin
作者单位: 1a Institute of Problems of Chemical Physics, Russian Academy of Sciences , Chernogolovka , Russia
2;b N.N. Blokhin Cancer Research Center, Russian Ministry of Health , Moscow , Russia
刊名: Journal of Coordination Chemistry, 2019, Vol.72 (5-7), pp.972-986
来源数据库: Taylor & Francis Journal
DOI: 10.1080/00958972.2019.1583331
关键词: Nitrosyl iron complexes2-MercaptobenzthiazoleNitric oxide donationApoptosis induction
原始语种摘要: Abstract(#br)Single-crystals of binuclear neutral sulfur-nitrosyl iron complex with 2-mercaptobenzthiazole ligand [Fe27н4NS2)2(NO)4] (BTz) have been obtained. From X-ray data, BTz has a centrosymmetric dimeric structure, with the iron atoms being linked through the µ-N-C-S bridge. As follows from mass-spectra of the BTz gas phase, the complex is stable in the crystalline state under normal conditions (ambient temperature and standard humidity) and releases nitric oxide upon heating. Using amperometry, kinetics of NO release by BTz in 1% dimethyl sulfoxide aqueous solution has been studied: release of NO was shown to occur immediately upon dissolution in protic media. BTz inhibited growth of K562 leukemia and...
全文获取路径: Taylor & Francis  (合作)
影响因子:1.801 (2012)

  • NO Normally Open
  • binuclear 双核的
  • complex 超群
  • solution 溶液
  • aqueous 水的
  • kinetics 动力学
  • activity 活度
  • studied 学习
  • nitric 氮的
  • oxide 氧化物