FAK-Src-paxillin system expression and disease outcome in human neuroblastoma
作者: Panagiotis KratimenosIoannis KoutroulisVasiliki SyriopoulouChristina MichailidiMaria Delivoria-PapadopoulosJerzy KlijanienkoStamatios Theocharis
作者单位: 1Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Children's National Medical Center , The George Washington University, School of Medicine and Health Sciences , Washington, DC , USA
2First Department of Pathology , National and Kapodistrian University of Athens, School of Medicine , Athens , Greece
3Department of Pediatrics, Division of Emergency Medicine, Children's National Medical Center , The George Washington University, School of Medicine and Health Sciences , Washington, DC , USA
4Department of Pathology , Institut Curie , Paris , France
5University of Pennsylvania School of Medicine , Department of Physiology , Philadelphia , PA , USA
6National and Kapodistrian University of Athens , School of Medicine, Children's Hospital of Athens, Department of Pediatrics , Athens , Greece
刊名: Pediatric Hematology and Oncology, 2017, Vol.34 (4), pp.221-230
来源数据库: Taylor & Francis Journal
DOI: 10.1080/08880018.2017.1360969
关键词: FAKNMYCNeuroblastomaPaxillinSrc
原始语种摘要: ABSTRACT(#br)Background:(#br) Neuroblastoma (NB) often presents with metastatic disease and poor survival. The need for new prognostic markers remains invaluable. The FAK-Src-Paxillin protein system is associated with aggressive phenotype in adult malignancies but is largely unexplored in pediatric NB. Objective:(#br) To assess FAK-Src-Paxillin protein expression in human NB cell lines and clinical cytology material and to delineate its association with survival. Design/Methods:(#br) Western blot and immunohistochemistry were applied for FAK-Src-Paxillin expression in NB cell lines and 23 human cytology specimens, respectively. Protein expression in human clinical samples was correlated with clinicopathological parameters, MYCN amplification and survival. Results:(#br) FAK, Src and...
全文获取路径: Taylor & Francis  (合作)
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影响因子:0.895 (2012)

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关键词翻译
关键词翻译
  • neuroblastoma 成神经细胞瘤
  • expression 表示
  • human 人的
  • survival 生存
  • outcome 效果
  • unfavorable 不利
  • protein 蛋白质
  • markers 时标
  • therapeutic 治疗的
  • delineate 描绘