Lycopene and Apo-12′-Lycopenal Reduce Cell Proliferation and Alter Cell Cycle Progression in Human Prostate Cancer Cells
作者: Nikki A. FordAmy C. ElsenKrystle ZunigaBrian L. LindshieldJohn W. Erdman
作者单位: 1Division of Nutritional Sciences , University of Illinois at Urbana-Champaign , Urbana , Illinois , USA
2Department of Food Science and Human Nutrition , University of Illinois at Urbana-Champaign , Urbana , Illinois , USA
刊名: Nutrition and Cancer, 2011, Vol.63 (2), pp.256-263
来源数据库: Taylor & Francis Journal
DOI: 10.1080/01635581.2011.523494
原始语种摘要: Lycopene is associated with a reduced risk of prostate cancer. However, lycopene may not be wholly responsible for the effects seen in vivo or in cell culture systems. Apo-lycopenals or other lycopene metabolites, whether produced by cleavage enzymes within the body or consumed with tomato products, can be found in tissues at concentrations equivalent to physiological retinoid concentrations. Therefore, it is plausible that lycopenoids, like retinoids, are bioactive within tissues. Androgen-independent DU145 prostate cancer cells were treated with lycopene, apo-8′-lycopenal, or apo-12′-lycopenal. DU145 cell proliferation was significantly reduced by supra-physiological levels of lycopene and apo-12′-lycopenal, in part, through alteration of the normal cell cycle. Levels of the gap...
全文获取路径: Taylor & Francis  (合作)
影响因子:2.695 (2012)