Quercetin, Siamois 1 and siamois 2 induce apoptosis in human breast cancer MDA-MB-435 cells xenograft in vivo
作者: Samarn DechsupaSuchart KothanJackie VergoteGerard LegerAntoine MartineauSimone BerangerRachian KosanlavitJean-Luc MorettiSamlee Mankhetkorn
刊名: Cancer Biology & Therapy, 2007, Vol.6 (1), pp.56-61
来源数据库: Taylor & Francis Journal
DOI: 10.4161/cbt.6.1.3548
原始语种摘要: We sought to investigate the apoptosis-inducing activities of quercetin, Siamois 1, and Siamois 2 against invasive estrogen-receptor negative MDA-MB 435 cells xenografted in athymic nude mice. This study clearly demonstrated that these compounds exhibited apoptosis-inducing activities in cell culture system. Quercetin (20 μg/mL), Siamois 1 (100 μg/mL), and Siamois 2 (200 μg/mL) can induce apoptotic cell death by 40± 5%, 44 ± 14 %, and 31 ± 13 %, respectively. Two-fold of IC50 of these compounds were clearly found to induce apoptosis in breast tumor tissue which can be determined by 99mTc-annexin V scintigraphy and histological staining. This is the first report that the apoptosis-inducing effects of quercetin, Siamois 1, and Siamois 2 on the MDA-MB 435 cell in vitro were...
全文获取路径: Taylor & Francis  (合作)
影响因子:3.287 (2012)