Chapter 1 Introduction to Protein Complex Prediction
作者: Sriganesh SrihariChern Han YongLimsoon Wong
作者单位: South Australian Health and Medical Research Institute (SAHMRI);;Duke-National University of Singapore Medical School;;National University of Singapore
英文丛书称: ACM Books
出版社: ACMMC,   2017
ISBN: 978-1-97000-155-6
来源数据库: Association for Computing Machinery
DOI: 10.1145/3064650.3064652
原始语种摘要: Complexes of physically interacting proteins constitute fundamental functional units that drive almost all biological processes within cells. A faithful reconstruction of the entire set of protein complexes (the “complexosome”) is therefore important not only to understand the composition of complexes but also the higher level functional organization within cells. Advances over the last several years, particularly through the use of high-throughput proteomics techniques, have made it possible to map substantial fractions of protein interactions (the “interactomes”) from model organisms including Arabidopsis thaliana (a flowering plant), Caenorhabditis elegans (a nematode), Drosophila melanogaster (fruit fly), and Saccharomyces cerevisiae (budding yeast). These interaction datasets have...
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关键词翻译
关键词翻译
  • understand 理解
  • computational 计算的
  • reconstruction 复原
  • protein 蛋白质
  • fundamental 基本的
  • efficient 有用的
  • accurate 精确的
  • human 人的
  • underpinning 加固基础
  • rewiring 重新布线