NOX3-Targeted Therapies for Inner Ear Pathologies
作者: Francis RoussetStephanie CarnesecchiPascal SennKarl-Heinz Krause
刊名: Current Pharmaceutical Design, 2015, Vol.21 (41), pp.5977-5987
来源数据库: Bentham Journal
DOI: 10.2174/1381612821666151029112421
关键词: NADPH oxidaseNOX3Oxidative stressVestibular systemCochleaHearing lossMolecular biology-based inhibitorsSmallmolecules inhibitors.
原始语种摘要: Inner ear pathologies are associated with major morbidity and loss of life quality in affected patients. Inmany of these conditions, production of reactive oxygen-species (ROS) is thought to be a key pathological mechanism.While the sources of ROS are complex (including for example mitochondria), there is increasing evidencethat activation of NOX enzymes, in particular NOX3, plays a key role. NOX3 is a multi-subunit NADPH oxidase,functionally and structurally closely related to NOX1 and NOX2. In both the vestibular and the cochlear compartmentsof the inner ear, high levels of NOX3 mRNA are expressed. In NOX3 mutant mice, the vestibular function isperturbed due to a lack of otoconia, while only minor alterations of hearing have been documented. However, thereis increasing evidence that...
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影响因子:3.311 (2012)

  • hearing 听觉
  • otoconia 耳石
  • vestibular 前厅的
  • cochlear 蜗状物的
  • targeted 对准目标的
  • inner 内的
  • pathological 病理学的
  • NADPH 还原型烟酰胺腺嘌呤二核苷酸磷酸
  • mitochondria 线粒体
  • therapeutic 治疗的