In the rapidly advancing field of genomics, microarray technologies have turned into a ground-breaking system on simultaneous monitoring the expression patterns of multiple genes under various arrangements of constraints. A fundamental errand is to propose diagnostic techniques to distinguishcluster of genes comparative expression designs and are initiated by comparative conditions. And furthermore, the relating investigation has issue is to cluster multi-condition gene expression data. To overcome these issues, the vast measure of data obtained by this technology, resort to clusteringmethods that distinguish clusters of genes of share similar expression profiles. The motivation of this work is to introduce a clustering method in microarray gene expression data analysis. Multi-Objective... Binary Particle Swarm Optimization with Fuzzy Weighted Clustering (MOBPSOFWC algorithmis proposed to analyze gene expression data. In high dimensionality, a quick heuristic based pre-processing technique is employed to diminish some of the basic domain features from the initial feature set. Since these pre-processed and reduced features are still high dimensional, the proposedMOBPSO algorithm is implemented in MATLAB tool used for finding further feature subsets. The investigative are directed to distinguish the execution of the proposed work with existing clustering approaches.