The prevalence of HIV in Bangladesh is not alarming but the trend is. Every year the number of newly diagnosed infection is increasing along with the number of death due to AIDS and AIDS associated diseases. Prevalence has been found quite high among the injection drug users and the migrant workers. Particular populations, such as, homosexuals, transgender people are under-represented in the HIV studies and surveillances and these populations are the one most at risk. Due to the conservative society standard, these populations tend to stay underground. Most HIV infected people are unaware of their infections; those who are aware of their infection are not always under treatment. Rather they are outlawed from their families and often they lose their jobs. Initiatives have been taken... globally to end HIV by 2030. Bangladesh has been lagged behind in this battle against HIV. Thus, strategies to work on HIV response with detailed action plans on prevention, treatment, service, research, and surveillance have been taken to meet the global challenge.