In order to analyse users' acceptance of an innovative product in the information age, this study investigates the relationships among perceived ease of use, usefulness, enjoyment, and purchase intention of smart clothing based on bio-signal. This study considers the fashion innovation and technology innovation to understand potential users' characteristics of innovative products. To achieve objectives of this study, we carry out the survey targeting reading groups, and providing them with pictures of biomedical smart clothes. Perceived ease of use and benefit had a positive effect on the purchase intention in Korea, but did not have an effect on the purchase intention in China. The results of the difference analysis shows that the fashion innovation perceiving the Chinese customers had a... greater impact the perceived ease of use and usefulness than the Korea customers. This study provides various insights on the market for innovative products, suggesting that our results may be useful to both companies and researchers.