Design, Development and Evaluation of Oxcarbazepine Loaded Fast Dissolving Oral Film
作者: Pooja RDSayyad FJ
刊名: International Journal of Drug Development and Research, 2018, Vol.10 (3), pp.1-13
来源数据库: Insight Medical Publishing
关键词: Fast dissolving filmsOxcarbazepineSolvent casting techniqueWater-soluble polymers
原始语种摘要: The present study was aimed to develop a novel fast dissolving drug delivery system for an antiepileptic drug such as Oxcarbazepine. The fast dissolving films were prepared by solvent casting technique using water-soluble polymers such as hydroxyl propyl methylcellulose HPMC E-5 LV, E-50 LV. In this study PEG 400 was used as plasticizer and Mannitol was used as a sweetener. Concentration of water soluble polymers were optimized during preliminary studies. The prepared films were evaluated for thickness, weight uniformity, drug content, surface pH, folding endurance, tensile strength, percent elongation, in-vitro disintegration time, swelling index and in-vitro drug release studies. The results obtained showed no physical chemical incompatibility between the drug and the polymers. The...
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  • dissolving 溶解
  • films 薄膜
  • thickness 厚度
  • tensile 拉的
  • soluble 可溶的
  • prepared 有准备的
  • sweetener 增甜剂
  • transparent 透媚
  • elongation 伸长
  • casting 铸模