Human Umbilical Cord Mesenchymal Stem Cells Ameliorate Silver Nanoparticles Induced Sub-chronic Lung toxicity in Adult Male Albino Rats
作者: Arwa A. El-Sheikh Samaa Salah Abd El-Fatah Rania Said Moawadand Doaa Mohammed Yousef
刊名: Life Science Journal, 2018, Vol.15 (10)
来源数据库: Marsland Press
DOI: 10.7537/marslsj151018.05
关键词: Silver nanoparticlesHuman mesenchymal stem cellsNitric oxideMyeloperoxidaseUltra-structuralLung
原始语种摘要: Background: Silver nanoparticles (Ag-NPs) arenanomaterials that become used widely in several applications and products. Objective: The current work aimed at studying the Ag-NPs effects on the lung tissues of adult male albino rats and to evaluate the potential ameliorating role of human umbilical cord mesenchymal stem cells (HUCMSCs) through biochemical, histopathological, immunhistochemical and ultra-structural lung tissues examinations. Material and methods: thirty adult male albino rats were divided into control groups (I), Ag-NPs group (II), received (300mg/kg) of Ag-NPs orally by gavage and Ag-NPs+ HUCMSCs (III), received Ag-NPs as group II and (0.5 × 106)/80 μl PBS of HUCMSCs by intravenous injection in rat tail vein for the two successive days after 4 weeks of AG-NPs...
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  • Silver 
  • toxicity 毒性
  • albino 白化体
  • structural 构造
  • mesenchymal 间叶细胞的
  • induced 感应的
  • potential 
  • cells 麻风细胞
  • adult 成体
  • GSH 谷胱甘肽