Synergistic lethal effect between PI3K/mTOR inhibitor Voxtalisib and arsenic trioxide on human leukemic KG-1 cell line
作者: Pin Wu, Hongying ChaoRi Zhang Suning Chen
刊名: Life Science Journal, 2018, Vol.15 (10)
来源数据库: Marsland Press
DOI: 10.7537/marslsj151018.11
关键词: 8p11 myeloproliferative syndromeVoxtalisibArsenic trioxideKG-1 cells
原始语种摘要: Myeloid/lymphoid neoplasms with FGFR1 rearrangement (also known as 8p11 myeloproliferative syndrome, EMS) is a distinct disease entity in the current WHO classification. These patients frequently (~80%) progress to acute myeloid leukemia (AML) and have a poor outcome with a 5-year survival rate of < 20%. To identify the potential treatment regimen on these patients, the four reagents (Idarubicin, arsenic trioxide, Voxtalisib and Ruxolitinib) were applied on KG-1 cells. Our results showed that the KG-1 cell line was resistant to idarubicin. However, the dual PI3K/mTOR inhibitor Voxtalisib, rather than JAK1/2 inhibitor Ruxolitinib could be effectively against KG-1 cells. Arsenic trioxide (As2O3) combined with Voxtalisib synergistically inhibitted the viability of KG-1 cells. We also found...
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关键词翻译
关键词翻译
  • trioxide 三氧化物
  • leukemic 白血病的
  • arsenic 
  • effect 效应
  • inhibitor 抑制剂
  • lethal 致死
  • leukemia 白血病
  • cells 麻风细胞
  • myeloid 骨髓的
  • human 人的