Simultaneous and Fast SPE-HPLC Analyses of Nine Anti-Hypertensive Drugs in Human Plasma
作者: Imran AliKamlesh K. DuttaA.K. JainMohd. AsimSyed Dilshad Alam
刊名: Open Journal of Advanced Drug Delivery, 2015, Vol.3 (2), pp.123-134
来源数据库: Pubicon International Publications
原始语种摘要: Objectives: Increasing cardiovascular patients is a matter of global issue. Various drugs are being used to cure these ailments with different mode of actions. The present article describes simultaneous and Fast SPE-HPLC analyses of nine anti-hypertensive drugs in human plasma.Methods: Cardiovascular drugs such as amiloride, metoprolol, hydrochlorothiazide, carvidilol, amlodipine, fusemide, telmisertan, losartan and olmesartan were separated by HPLC on Sushell C8 (150 x 4.6 mm, 2.6 µm) column. The mobile phase was phosphate buffer (65% with 0.8% TEA) in acetonitrile; 0.5 mL/min flow rate, 230 nm detection and 40±1ºC temperature.Results: The values of retention, separation and resolution factors were from 0.19-3.40, 1.20-3.60 and 2.43-12.37, respectively. The values of retention times,...
全文获取路径: Pubicon 国际出版社 

  • hypertensive 高血压的
  • metoprolol 美托洛尔
  • retention 保留
  • amiloride 阿米洛利
  • phosphate 磷酸盐
  • drugs 药品
  • plasma 深绿玉髓
  • acetonitrile 乙腈
  • SPE 专用设备
  • tailing 尾矿