Stability Indicating RP-HPLC Method for Determination of Drotaverine HCL and Mefenamic Acid in Pure and Pharmaceutical Formulation
作者: Pallavi A. PatilA.R. UmarkarM.M. BariS.D. Barhate
刊名: Open Journal of Advanced Drug Delivery, 2015, Vol.3 (2), pp.110-122
来源数据库: Pubicon International Publications
原始语种摘要: Objective: A Stability indicating Reverse-Phase liquid chromatographic method for the simultaneous estimation of Drotaverine HCl and Mefenamic acid was developed.Method: The chromatographic assay involves the use of Hi Q C-18 W (5µm column with a simple mobile phase containing 80:20% v/v of methanol & HPLC Grade water (0.1% triethylamine at pH 3) with flow rate of 1.0mL/min with UV detection at wavelength of 250 nm. Result: The method showed good linearity in the concentration range of 2-10 μg/mL for Drotaverine Hcl and 6-30 μg/mL for Mefenamic Acid.Conclusion: The developed method was successfully validated as per the ICH guidelines. The stability indicating capacity was also tested and successfully applied to marketed formulation.
全文获取路径: Pubicon 国际出版社 
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关键词翻译
关键词翻译
  • triethylamine 三乙胺
  • liquid 液体
  • indicating 指示
  • successfully 成功地
  • estimation 估计
  • water 
  • formulation 配方
  • phase 相位
  • concentration 浓度
  • developed 开发