The investigation was carried out to determine qualitatively the phytoconstituents from the methanol and petroleum ether extracts of Drynaria quercifolia Linn. rhizome. Among the phytochemical screening of these extract, methanolic extract showed high number of constituents like alcohol, carbohydrates, phytosterols, phenols, tannins, flavonoids, proteins and aminoacids, steroids, saponins, cholinergic acids, glycosides, and resins than petroleum ether extract. In this study, we also analyzing the potent bioactive compounds in the methanol extract using Gas Chromatography-Mass Spectroscopy. Thirty compounds have been identified from GC-MS analysis. Some of them found in high concentration which were identified by high peak values. Medicinal potential of these components needs further... research on toxicological aspects to develop safe drug.