Discordance between EGFR Expression and Clinicopathologic Parameters of Colorectal Adenocarcinoma in Taiwan
作者: Wen-Chiuan TsaiChih-Kung LinHerng-Sheng LeeAnn ChenShin NiehCheng-Ping YuChang-Chieh WuShu-Wen JaoJong-Shiaw Jin
刊名: The Chinese Journal of Physiology, 2012, Vol.55 (5), pp.352-360
来源数据库: Airiti Inc.
DOI: 10.4077/CJP.2012.BAA061
关键词: Colorectal adenocarcinomaEGFRKi67P53Tissue microarray
英文摘要: Dysregulation of epidermal growth factor receptor (EGFR) has been associated with colorectal cancer, but no evidence shows a relationship of EGFR expression to clinicopathological parameters in colorectal cancer in Taiwan. Immunohistochemical analysis of EGFR, Ki67, and p53 was performed in tissue microarray slides of 9 normal glandular tissues and 150 specimens including 49 well, 58 moderately, and 43 poorly differentiated colorectal adenocarcinomas. Differences in intensity of EGFR immunostaining and the percentages of Ki67 and p53 positive cells between normal and tumor specimens were evaluated using the Student t-test, one-way ANOVA, and linear regression analysis. Intensity of EGFR staining was weak and nuclear expression of Ki67 and p53 was scattered in all 9 control specimens....
原始语种摘要: Dysregulation of epidermal growth factor receptor (EGFR) has been associated with colorectal cancer, but no evidence shows a relationship of EGFR expression to clinicopathological parameters in colorectal cancer in Taiwan. Immunohistochemical analysis of EGFR, Ki67, and p53 was performed in tissue microarray slides of 9 normal glandular tissues and 150 specimens including 49 well, 58 moderately, and 43 poorly differentiated colorectal adenocarcinomas. Differences in intensity of EGFR immunostaining and the percentages of Ki67 and p53 positive cells between normal and tumor specimens were evaluated using the Student t-test, one-way ANOVA, and linear regression analysis. Intensity of EGFR staining was weak and nuclear expression of Ki67 and p53 was scattered in all 9 control specimens....
全文获取路径: Airiti 
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影响因子:0.748 (2012)

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关键词翻译
关键词翻译
  • adenocarcinoma 腺癌
  • colorectal 结肠直肠的
  • moderately 适度地
  • significantly 较大地
  • stage 
  • correlated 相关
  • normal 法线
  • staining 染色
  • controls 控制机构
  • epidermal 上皮的