Anticonvulsant valproic acid and other short-chain fatty acids as novel anticancer therapeutics: Possibilities and challenges
作者: Katarzyna LipskaAnna GumieniczekAgata A. Filip
作者单位: 1Chair and Department of Medicinal Chemistry , Medical University of Lublin 20-090 Lublin , Poland
2 Department of Cancer Genetics with Cytogenetics Laboratory , Medical University of Lublin , 20-080 Lublin Poland
刊名: Acta Pharmaceutica, 2020, Vol.70 (3), pp.291-301
来源数据库: De Gruyter Journal
DOI: 10.2478/acph-2020-0021
关键词: Valproic acidShort-chain fatty acidsAnticancer activitiesHistone deacetylase inhibitorsPre-clinical and clinical studies
原始语种摘要: Abstract Results from numerous pre-clinical studies suggest that a well known anticonvulsant drug valproic acid (VPA) and other short-chain fatty acids (SCFAs) cause significant inhibition of cancer cell proliferation by modulating multiple signaling pathways. First of all, they act as histone deacetylase (HDAC) inhibitors (HDIs), being involved in the epigenetic regulation of gene expression. Afterward, VPA is shown to induce apoptosis and cell differentiation, as well as regulate Notch signaling. Moreover, it up-regulates the expression of certain G protein-coupled receptors (GPCRs), which are involved in various signaling pathways associated with cancer. As a consequence, some pre-clinical and clinical trials were carried out to estimate anticancer effectiveness of VPA, in monotherapy...
全文获取路径: De Gruyter 

  • fatty 脂肪的
  • chain 
  • novel 长篇小说
  • anticancer 抗癌的
  • expression 表示
  • involved 涉及
  • numerous 许多的
  • epigenetic 后成的
  • estimate 估计
  • anticonvulsant 镇痉剂