Simultaneous spectrofluorometric analysis of tablets containing hydrochlorothiazide combined with timolol maleate or amiloride hydrochloride
作者: Fadel WedianAnas LataifehMakaseb S. Mohammed
作者单位: 1Department of Chemistry Faculty of Science , Yarmouk University P.O. Box 560, Irbid 22163, Jordan
2 Department of Chemistry Faculty of Science , Tafila Technical University , Tafila 66110 , Jordan
刊名: Acta Pharmaceutica, 2020, Vol.70 (3), pp.373-385
来源数据库: De Gruyter Journal
DOI: 10.2478/acph-2020-0027
关键词: HydrochlorothiazideAmiloride hydrochlorideTimolol maleateFixed-dose combinationsSpectrofluorometryAssayingScreening
原始语种摘要: Abstract Green and sensitive spectrofluorometric methods have been developed and validated for the determination of timolol maleate (TML)/hydrochlorothiazide (HCT) and amiloride hydrochloride (AMH)/hydrochlorothiazide in tablets. The proposed spectrofluorometric procedures were found to be linear in the range of 4–12, 5–35 and 0.025–0.2 mg L−1 for HCT, TML and AMH, resp. The excitation and emission wavelengths for HCT, TML and AMH at room temperature were 270 and 375, 295 and 435, 330 and 415 nm, resp. The methods were validated with respect to ICH guidelines. The AMH showed higher sensitivity with lower values of LOD and LOQ values compared to HCT and TML. The proposed methods were applied to two pharmaceutical formulations; the method for HCT and AMH has proven as reliable...
全文获取路径: De Gruyter 

  • hydrochloride 盐酸盐
  • amiloride 阿米洛利
  • tablets 平片体
  • maleate 马来酸盐
  • timolol 噻吗咯尔
  • combined 组合
  • TML Tutorial and message Library
  • screening 筛分
  • pharmaceutical 
  • values 价值观