Toxicological evaluation of flumequine in pubertal male rats after oral administration for six weeks
作者: JeongWoo KangMd Akil HossainByungkook ChoiJoon-Hyoung ChoSeok-Jin KangHyun-Ok KuSang-Hee JeongHwan-Goo Kang
作者单位: 1Veterinary Drugs and Biologics Division, Animal and Plant Quarantine Agency , 177, Hyeoksin 8-ro, Gimcheon-si , Gyeongsangbuk-do 39660 , Republic of Korea
2 GLP Research Center, College of Natural Sciences , Hoseo University , 165, Asan City , Republic of Korea
刊名: Journal of Veterinary Research, 2018, Vol.62 (1), pp.87-96
来源数据库: De Gruyter Journal
DOI: 10.2478/jvetres-2018-0012
关键词: Male ratsFlumequineToxicityPituitary glandThyroid gland
原始语种摘要: Abstract Introduction: Veterinarians use flumequine (FLU) widely but its toxicological effects are still unclear. Material and Methods: FLU doses of 53, 200, or 750 mg/kg were administered orally for six weeks to pubertal male rats for evaluation of their toxicity. Results: Weight gain was poorer after seven days of exposure to FLU 750, but relative weights of the brain, adrenal and thyroid glands, and testes were notably higher. Haematological and lipid profile parameters, cardiac markers, and inorganic phosphate significantly increased in the FLU 750 group. Blood glucose, oestradiol and serum concentrations of immunoglobulins G (IgG) and E (IgE) significantly decreased after treatment. The levels of interleukins 10 (IL-10) and 6 (IL-6) fell significantly in the FLU 200 and FLU 750...
全文获取路径: De Gruyter 

  • flumequine 氟甲喹
  • pubertal 青春期的
  • after 在之后
  • amplified verification扩大核查
  • increased 增加
  • pituitary 垂体的
  • relative 相对的
  • gland 
  • subfamily 亚科
  • expression 表示