CHILDREN OF THE SUN, CHILDREN OF THE MOON – A MINI-PANEL FOR ASSESSMENT OF INTER-INDIVIDUAL VARIATION BETWEEN THE CAPACITY OF HEALTHY INDIVIDUALS TO REPAIR EVERYDAY GENOTOXIC INSULTS
作者: Zlatina ChichevaPavlina ChelenkovaRumena PetkovaStoyan Chakarov
作者单位: 1Scientific Technological Service (STS) Ltd., Sofia, Bulgaria
2Sofia University “St. Kliment Ohridski”, Faculty of Biology, Sofia, Bulgaria
刊名: Biotechnology & Biotechnological Equipment, 2012, Vol.26 (4), pp.3142-3147
来源数据库: Diagnosis Press Journal
DOI: 10.5504/bbeq.2012.0052
关键词: p53XPCtelomere lengthrisk assessmentgenotoxic damage
原始语种摘要: The DNA repair machinery of healthy human cells usually manages the consequences of the daily barrage of DNA damage for years and decades before any adverse effects related to genotoxic impact become manifest. There is significant variance, however, even between healthy individuals, in regard to their ability to detect and repair genotoxic damage. Some aspects of this variance exist throughout the life of the individual (genetic factors, such as polymorphisms in genes coding for products acting in the repair of DNA damage), while others (e.g. telomere length) may be the outcome of the genotype-phenotype interplay, modified by environmental factors. Numerous markers for assessment of capacity to combat genotoxic damage have been described so far, with only some of them having a value of...
全文获取路径: Diagnosis Press 
分享到:

×
关键词翻译
关键词翻译
  • variance 离散
  • machinery 机械
  • their 他们的
  • products 制品
  • healthy 健康的
  • years 年代
  • provide 规定
  • become 成为
  • panel 
  • ability 能力