|作者：||Qibin Qi, Mary K. Downer, Tuomas O. Kilpeläinen, H. Rob Taal, Sheila J. Barton, Ioanna Ntalla, Marie Standl, Vesna Boraska, Ville Huikari, Jessica C. Kiefte-de Jong, Antje Käörner, Timo A. Lakka, Gaifen Liu, Jessica Magnusson, Masayuki Okuda, Olli Raitakari, Rebecca Richmond, Robert A. Scott, Mark E.S. Bailey, Kathrin Scheuermann, John W. Holloway, Hazel Inskip, Carmen R. Isasi, Yasmin Mossavar-Rahmani, Vincent W.V. Jaddoe, Jaana Laitinen, Virpi Lindi, Erik Meläöén, Yannis Pitsiladis, Niina Pitkäöé|
11Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY
22Department of Nutrition, Harvard School of Public Health, Boston, MA
33MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital and University of Cambridge, Cambridge, U.K.
44The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
55The Generation R Study Group, Erasmus Medical Center, Rotterdam, the Netherlands
66Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands
77Department of Pediatrics, Erasmus Medical Center, Rotterdam, the Netherlands
88MRC Lifecourse Epidemiology Unit, Faculty of Medicine, University of Southampton, Southampton, U.K.
99Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece
1010Department of Health Sciences, University of Leicester, Leicester, U.K.
1111Institute of Epidemiology I, Helmholtz Zentrum Mäöéäünchen-German Research Center for Environmental Health, Neuherberg, Germany
1212Wellcome Trust Sanger Institute, Hixton, Cambridge, U.K.
1313Department of Medical Biology, University of Split School of Medicine, Split, Croatia
1414Institute of Health Sciences, University of Oulu, Oulu, Finland
1515Global Public Health, Leiden University College, Hague, the Netherlands
1616Pediatric Research Center, Department of Women’s & Child Health, University of Leipzig, Leipzig, Germany
1717Institute of Biomedicine, Department of Physiology, University of Eastern Finland, Kuopio, Finland
1818Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland
1919Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
2020Department of Neurology, Beijing Tian Tan Hospital, Capital Medical University, Beijing, People’s Republic of China
2121Institute of Environmental Medicine, Karolinska Institutet, and Sachs’ Children and Youth Hospital, Stockholm, Sweden
2222Graduate School of Science and Engineering, Yamaguchi University, Ube, Japan
2323The Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
2424Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland
2525MRC Integrative Epidemiology Unit, University of Bristol, Bristol, U.K.
2626School of Life Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, U.K.
2727Human Genetics and Medical Genomics, Faculty of Medicine, University of Southampton, Southampton, U.K.
2828Finnish Institute of Occupational Health, Oulu, Finland
2929Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
3030Georgia Prevention Center, Department of Pediatrics, Georgia Regents University, Augusta, GA
3131Hokkaido Nursing College, Chuo-ku, Sapporo, Japan
3232The Genetics of Obesity and Related Metabolic Traits Program, The Charles Bronfman Institute for Personalized Medicine, The Mindich Child Health and Development Institute, Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY
3333Department of Epidemiology, Harvard School of Public Health, Boston, MA
3434Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
|刊名：||Diabetes, 2015, Vol.64 (7), pp.2467-2476|
|来源数据库：||Duke University Press|
|原始语种摘要：||The FTO gene harbors variation with the strongest effect on adiposity and obesity risk. Previous data support a role for FTO variation in influencing food intake. We conducted a combined analysis of 16,094 boys and girls aged 1–18 years from 14 studies to examine the following: 1) the association between the FTO rs9939609 variant (or a proxy) and total energy and macronutrient intake; and 2) the interaction between the FTO variant and dietary intake, and the effect on BMI. We found that the BMI-increasing allele (minor allele) of the FTO variant was associated with increased total energy intake (effect per allele = 14.3 kcal/day [95% CI 5.9, 22.7 kcal/day], P = 6.5 × 10−4), but not with protein, carbohydrate, or fat intake. We also found that protein intake modified the association... between the FTO variant and BMI (interactive effect per allele = 0.08 SD [0.03, 0.12 SD], P for interaction = 7.2 × 10−4): the association between FTO genotype and BMI was much stronger in individuals with high protein intake (effect per allele = 0.10 SD [0.07, 0.13 SD], P = 8.2 × 10−10) than in those with low intake (effect per allele = 0.04 SD [0.01, 0.07 SD], P = 0.02). Our results suggest that the FTO variant that confers a predisposition to higher BMI is associated with higher total energy intake, and that lower dietary protein intake attenuates the association between FTO genotype and adiposity in children and adolescents.|