A biomechanical study of the role of sitagliptin on the bone characteristics of diabetic rats
作者: Stavros K KourkoulisErmioni PasiouArezoo AbdiDespoina PerreaJohn Vlamis
作者单位: 1National Technical University of Athens, Greece
2National Technical University of Athens
刊名: Frattura ed Integrità Strutturale, 2020, Vol.14 (51), pp.127-135
来源数据库: Gruppo Italiano Frattura
DOI: 10.3221/IGF-ESIS.51.10
关键词: Male Wistar ratsType-2 diabetesSitagliptinBiomechanicsThree point bendingVideo-extensometer
原始语种摘要: An experimental protocol is described aiming to explore the in­fluence of Type 2 Diabetes Mellitus on the biomechanical response of the bone tissue and, also, to quantify the potential beneficial role of a pharma­ceutical treatment, based on sitagliptin, a diabetes drug that increases the levels of natural substances called incretins. Twenty eight male, 10-week old Wistar rats were used, divided into three groups, i.e., the control one, the group including the diabetic rats and, finally, the group including the diabetic rats which were treated using sitagliptin. The biomechanical study was based on a series of three-point bending tests of the femora of the sacrificed rats and the analysis of the experimental data was implemented in terms of the actual geometry of the fractured...
全文获取路径: Gruppo Italiano Frattura 

  • diabetic 糖尿病患者
  • diabetes 糖尿病
  • stiffness 刚性
  • extensometer 伸长计
  • beneficial 有利
  • bending 弯曲
  • experimental 实验的
  • undertake 承担
  • effect 效应
  • section 薄片