Molecular Mechanisms of Ultraviolet Radiation-Induced DNA Damage and Repair
作者: Rajesh P. RastogiRichaAshok KumarMadhu B. TyagiRajeshwar P. SinhaShigenori Iwai
作者单位: 1Laboratory of Photobiology and Molecular Microbiology, Centre of Advanced Study in Botany, Banaras Hindu University, Varanasi 221005, India
2School of Biotechnology, Banaras Hindu University, Varanasi 221005, India
3Mahila Maha Vidyalaya, Banaras Hindu University, Varanasi 221005, India
刊名: Journal of Nucleic Acids, 2010, Vol.2010
来源数据库: Hindawi Journal
DOI: 10.4061/2010/592980
原始语种摘要: DNA is one of the prime molecules, and its stability is of utmost importance for proper functioning and existence of all living systems. Genotoxic chemicals and radiations exert adverse effects on genome stability. Ultraviolet radiation (UVR) (mainly UV-B: 280–315 nm) is one of the powerful agents that can alter the normal state of life by inducing a variety of mutagenic and cytotoxic DNA lesions such as cyclobutane-pyrimidine dimers (CPDs), 6-4 photoproducts (6-4PPs), and their Dewar valence isomers as well as DNA strand breaks by interfering the genome integrity. To counteract these lesions, organisms have developed a number of highly conserved repair mechanisms such as photoreactivation, base excision repair (BER), nucleotide excision repair (NER), and mismatch repair (MMR)....
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  • homologous 同结构型的
  • DNA Deoxyribonucleic Acid
  • nucleotide 核苷酸
  • interfering 干涉
  • strand 海滨
  • powerful 强大的
  • proper 合适的
  • breaks 劣地形
  • excision 切除
  • repair 修理