Antiproliferative and Apoptosis-Inducing Activities of 4-Isopropyl-2,6-bis(1-phenylethyl)phenol Isolated from Butanol Fraction of Cordyceps bassiana
作者: Ji Hye KimYunmi LeeGi-Ho SungHan Gyung KimDeok JeongJae Gwang ParkKwang-Soo BaekNak Yoon SungSungjae YangDeok Hyo YoonSang Yeol LeeHyojeung KangChangsik SongJae Han ChoKang-Hyo LeeTae Woong KimJae Youl ChoYew-Min Tzeng
作者单位: 1Department of Genetic Engineering, Sungkyunkwan University, Suwon 440-746, Republic of Korea
2Department of Chemistry, Kwangwoon University, Seoul 139-701, Republic of Korea
3Institute for Bio-Medical Convergence, International St. Mary’s Hospital and College of Medicine, Catholic Kwandong University, Incheon 404-834, Republic of Korea
4Department of Biochemistry, Kangwon National University, Chuncheon 220-700, Republic of Korea
5Department of Life Science, Gachon University, Seongnam, Kyeonggi-do 461-701, Republic of Korea
6College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 702-701, Republic of Korea
7Department of Chemistry, Sungkyunkwan University, Suwon 440-746, Republic of Korea
8Mushroom Research Division, Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Suwon 441-707, Republic of Korea
9Department of Biochemistry, Kangwon National University, Chuncheon 200-701, Republic of Korea
刊名: Evidence-Based Complementary and Alternative Medicine, 2015, Vol.2015
来源数据库: Hindawi Journal
DOI: 10.1155/2015/739874
原始语种摘要: The Cordyceps species have been widely used for treating various cancer diseases. Although the Cordyceps species have been widely known as an alternative anticancer remedy, which compounds are responsible for their anticancer activity is not fully understood. In this study, therefore, we examined the anticancer activity of 5 isolated compounds derived from the butanol fraction (Cb-BF) of Cordyceps bassiana . For this purpose, several cancer cell lines such as C6 glioma, MDA-MB-231, and A549 cells were employed and details of anticancer mechanism were further investigated. Of 5 compounds isolated by activity-guided fractionation from BF of Cb-EE, KTH-13, and 4-isopropyl-2,6-bis(1-phenylethyl)phenol, Cb-BF was found to be the most potent antiproliferative inhibitor of C6 glioma and...
全文获取路径: Hindawi 

  • Cordyceps 冬虫夏草
  • anticancer 抗癌的
  • glioma 神经胶质瘤
  • activity 活度
  • inhibitor 抑制剂
  • lines 线型
  • potent 强大的
  • laddering 纵向脱散
  • isopropyl 异丙基
  • remedy 疗法