Copper Uptake in Mammary Epithelial Cells Activates Cyclins and Triggers Antioxidant Response
作者: Nathália Villa dos SantosAndreza Cândido MatiasGuilherme Shigueto Vilar HigaAlexandre Hiroaki KiharaGiselle CerchiaroJoseph A. Adeyemi
作者单位: 1Center for Natural Sciences and Humanities, Federal University of ABC (UFABC), 09210-170 Santo André, SP, Brazil
2Center for Mathematics, Computation and Cognition, Federal University of ABC (UFABC), 09210-170 Santo André, SP, Brazil
刊名: Oxidative Medicine and Cellular Longevity, 2015, Vol.2015
来源数据库: Hindawi Journal
DOI: 10.1155/2015/162876
原始语种摘要: The toxicologic effects of copper (Cu) on tumor cells have been studied during the past decades, and it is suggested that Cu ion may trigger antiproliferative effects in vitro . However, in normal cells the toxicologic effects of high exposures of free Cu are not well understood. In this work, Cu uptake, the expression of genes associated with cell cycle regulation, and the levels of ROS production and related oxidative processes were evaluated in Cu-treated mammary epithelial MCF10A nontumoral cells. We have shown that the Cu additive is associated with the activation of cyclin D1 and cyclin B1, as well as cyclin-dependent kinase 2 (CDK2). These nontumor cells respond to Cu-induced changes in the oxidative balance by increase of the levels of reduced intracellular glutathione (GSH),...
全文获取路径: Hindawi 
影响因子:3.393 (2012)

  • toxicologic 毒理学
  • cyclin 细胞周期蛋白
  • normal 法线
  • cells 麻风细胞
  • oxidative 氧化的
  • induced 感应的
  • mammary 乳房的
  • understood 明白
  • respond 应答
  • activation 活化