Synthesis, Characterization and in vitro Antimicrobial Screening of Some Novel Series of 2-Azetidinone Derivatives Integrated with Quinoline, Pyrazole and Benzofuran Moieties
作者: M. Idrees Y.G. Bodkhe N.J. SiddiquiS.S. Kola
刊名: Asian Journal of Chemistry, 2020, Vol.32 (4)
来源数据库: Asian Journal of Chemistry
DOI: 10.14233/ajchem.2020.22490
关键词: AzetidinonesP-TolyloxyQuinoline carbaldehydePyrazoleCarbohydrazides.
原始语种摘要: A series of 5-(benzofuran-2-yl)-N-(3-chloro-4-(2-(p-tolyloxy) substituted quinolin-3-yl)-2-oxoazetidin- 1-yl)-1-phenyl-1H-pyrazole-3-carboxamide derivatives (4a-f) were synthesized with excellent yields by cyclocondensation reaction of 5-(benzofuran-2-yl)-N′-(2-(p-tolyloxy) substituted quinolin-3- yl)methylene)-1-phenyl-1H-pyrazole-3-carbohydrazide (3a-f) with chloroacetyl chloride in presence of triethylamine in DMF. One pot condensation of 5-(benzofuran-2-yl)-1-phenyl-1H-pyrazole-3- carbohydrazide (1) with 2-(p-tolyloxy) substituted quinoline-3-carbaldehyde (2a-f) in ethanol solvent in presence of catalytic amount of acetic acid gave intermediate compounds (3a-f). The structures of newly synthesized compounds have been substantiated through elemental analysis and spectral studies viz....
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  • carbohydrazide 碳酰肼
  • phenyl 苯基
  • pyrazole 吡唑
  • triethylamine 三乙胺
  • substituted 取代的
  • elemental 元素的
  • benzofuran 苯并呋喃
  • antibacterial 抗细菌的
  • carboxamide 氨甲酰
  • methylene 甲叉