An Efficient and Green Synthesis of Fluorine Containing Benzo[a]xanthen-11(12H)-ones and Evaluation of their Anticancer Activity
作者: J. Sumalatha A. SreedeviC. Radha Rani
刊名: Asian Journal of Chemistry, 2020, Vol.32 (4)
来源数据库: Asian Journal of Chemistry
DOI: 10.14233/ajchem.2020.22503
关键词: FluorineBenzo[a]xanthen-11(12H)-onesNaphthalene-diolsAnticancer activity.
原始语种摘要: A facile and an efficient procedure has been developed by one-pot condensation of naphthalene-diols, fluoro substituted benzaldehydes and cyclic 1,3-dicarbonyl compounds for the synthesis of fluorine containing benzo[a]xanthen-11(12H)-ones under the catalyst and solvent-free conditions. All the synthesized compounds were characterized by IR, NMR (1H & 13C) and mass spectrometry. Several advantages offer the present approach, such as, shorter reaction time, low cost, anticipation of toxic solvents and catalyst, higher yield of products and durability of substrate range. On the other hand, anticancer activity was also performed for the title compounds which demonstrated a significant activity on selected cancer cell lines.
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关键词翻译
关键词翻译
  • diols 二烯
  • facile 容易的
  • catalyst 催化剂
  • compounds 化合物
  • condensation 冷凝
  • substituted 取代的
  • fluorine 
  • fluoro 氟代
  • activity 活度
  • durability 持久性