Synthesis, Characterization & Antimicrobial Activities of New Isoxazole Substituted Mannich and Schiff Bases of 5-Nitroisatin Analogs
作者: Ch. Jithendra G. Saravanan V. Alagarsamy T. Panneerselvam K. SelvarajP. Parasuraman
刊名: Asian Journal of Chemistry, 2020, Vol.32 (4)
来源数据库: Asian Journal of Chemistry
DOI: 10.14233/ajchem.2020.22596
关键词: IsatinIsoxazole5-NitroisatinMicrobial activity.
原始语种摘要: A sequence of new isoxazole substituted Schiff base and Mannich base of 5-nitroisatin are synthesized by a multi-step synthesis from 5-nitroisatin. Whole synthesized analogs were characterized using IR, NMR, Mass spectroscopy and microanalyses. All the Schiff and Mannich bases were tested for their antimicrobial potencies against some human pathogenic microorganism using agar well diffusion technique. The relationship between the biological activity and the functional group variation of the Schiff and Mannich bases were analyzed. Standard ciprofloxacin and ketoconazole were used to compare the antimicrobial activities of novel isatin coupled isoxazole derivatives.
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  • ketoconazole 酮康唑
  • isoxazole 异恶唑
  • isatin 靛红
  • antimicrobial 杀菌剂
  • ciprofloxacin 卷须霉素
  • against 反对
  • bases 脱氧核糖核酸基盐
  • analogs 类似物
  • novel 长篇小说
  • functional 功能的