Solanum macrocarpon Leaf Extracts Reduced Blood Pressure and Heart Rate After Oral Administration to Spontaneously Hypertensive Rats
作者: Olayinka A. Oluwagunwa
刊名: Current Topics in Nutraceutical Research, 2019, Vol.17 (3)
来源数据库: New Century Health Publishers, LLC
关键词: Angiotensin converting enzymeBlood pressureHeart ratePolyphenolsReninSolanum macrocarponSpontaneously hypertensive ratsTelemetry
原始语种摘要: The aim of this work was to determine the ability of polyphenol-enriched aqueous vegetable leaf extracts to ameliorate blood pressure and heart rate dysfunctions in spontaneously hypertensive rats (SHRs). Solanum macrocarpon (SM), a common edible vegetable leaf in West Africa was cultivated using varying levels (0-80 kg/ha) of urea that was applied at planting (T1) or 2 weeks after planting (T2). In vitro analysis showed that total polyphenolic compounds varied from 489.87 ± 5.66 to 513.56 ± 1.42 mg gallic acid equivalent/g dry wt of extract. Rutin, caffeic acid and myricetin were the major polyphenols quantified in the extracts. All the extracts inhibited in vitro activities of renin and angiotensin converting enzyme to varying extents. Two extracts (SM40T1 and SM80T2) were orally...
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  • hypertensive 高血压的
  • converting 转换
  • extracts 摘记
  • Solanum 茄属
  • spontaneously 自发地
  • pressure 压力
  • polyphenols 多酚
  • angiotensin 血管紧张肽
  • gallic 制图布
  • systolic 脉动