Scutellarin Mitigates Cancer-Induced Bone Pain by Suppressing CaMKII/CREB Pathway in Rat Models
作者: Chenglong Liu
刊名: Current Topics in Nutraceutical Research, 2019, Vol.17 (3)
来源数据库: New Century Health Publishers, LLC
关键词: Ca2+/calmodulin-dependent protein kinase IICAMP-response element binding proteinCancer-induced bone painMechanical allodyniaScutellarinThermal hyperalgesia
原始语种摘要: Cancer-induced bone pain is a severe and complex pain caused by metastases to bone in cancer patients. The aim of this study was to investigate the analgesic effect of scutellarin on cancer-induced bone pain in rat models by intrathecal injection of Walker 256 carcinoma cells. Mechanical allodynia was determined by paw withdrawal threshold in response to mechanical stimulus, and thermal hyperalgesia was indicated by paw withdrawal latency in response to noxious thermal stimulus. The paw withdrawal threshold and paw withdrawal latencies were significantly decreased after inoculation of tumor cells, whereas administration of scutellarin significantly attenuated tumor cell inoculation-induced mechanical and heat hyperalgesia. Tumor cell inoculation-induced tumor growth was also significantly...
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  • protein 蛋白质
  • scutellarin 黄芩素
  • induced 感应的
  • withdrawal 取消
  • kinase 激酶
  • calmodulin 调钙蛋白
  • binding 装订
  • hyperalgesia 痛觉过敏
  • cAMP 环腺苷酸
  • Cancer 巨蟹座