Sulforaphane Modulates Metastasis Related Gene Expression and Cytokine Secretion in Mda-Mb-231 Breast Cancer Cells
作者: Mehdi Bagheri
刊名: Current Topics in Nutraceutical Research, 2019, Vol.17 (3)
来源数据库: New Century Health Publishers, LLC
关键词: AngiogenesisBreast cancer metastasisChemotactic factorsEpithelial mesenchymal transitionSulforaphane
原始语种摘要: Sulforaphane (SFN) a chemopreventive isothiocyanate found in cruciferous vegetables, exhibits antimetastatic properties. To address the possible molecular mechanisms underlying the antimetastatic activity of SFN we assessed the expression of some chemotactic factors, adhesion molecules, and key regulators of metastasis. For this purpose, MDA-MB-231 cells were treated with different concentrations of SFN. After 72 h, the inhibitory effects of SFN on the production of the cytokines and also expression of metastatic related genes were examined by enzyme-linked immunosorbent assay and, real-time PCR, respectively. Our results revealed that, SFN significantly decreased the secretion of TGFβ1, MCP1, and MMP9, while the level of IL8 was decreased only at high concentrations of SFN. Moreover, our...
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  • chemotactic 趋化性的
  • cytokines 细胞浆移动
  • isothiocyanate 异硫氰酸盐
  • immunosorbent 免疫吸收剂
  • expression 表示
  • mesenchymal 间叶细胞的
  • metastasis 同质蜕变
  • significantly 较大地
  • adjuvant 辅助剂
  • inhibitory 禁止的