Cancer prevalence is increased in females with sleep apnoea: data from the ESADA study
作者: Athanasia PatakaMaria R. BonsignoreSilke RyanRenata L. RihaJean-Louis PepinSofia SchizaOzen K. BasogluPawel SliwinskiOndrej LudkaPaschalis SteiropoulosUlla AnttalainenWalter T. McNicholasJan HednerLudger Grote
作者单位: 1Respiratory Failure Unit, G. Papanikolaou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece
2Biomedical Dept of Internal and Specialistic Medicine (DiBiMIS), Section of Pneumology, University of Palermo and CNR Institute of Biomedicine and Molecular Immunology, Palermo, Italy
3Pulmonary and Sleep Disorders Unit, St Vincent's University Hospital and School of Medicine, University College Dublin, Dublin, Ireland
4Dept of Sleep Medicine, Royal Infirmary Edinburgh, Edinburgh, UK
5University Grenoble Alpes, INSERM HP2 (U1042) and Grenoble University Hospital, Grenoble, France
6Sleep Disorders Unit, Dept of Respiratory Medicine, Medical School, University of Crete, Heraklion, Greece
7Dept of Chest Diseases, Ege University, Faculty of Medicine, Izmir, Turkey
82nd Dept of Respiratory Medicine, Institute of Tuberculosis and Lung Diseases, Warsaw, Poland
9Dept of Cardiology, University Hospital Brno and International Clinical Research Center, St. Ann's University Hospital, Brno, Czech Republic
10Sleep
刊名: European Respiratory Journal, 2019, Vol.53 (6)
来源数据库: European Respiratory Society
DOI: 10.1183/13993003.00091-2019
原始语种摘要: There is growing, but debatable evidence for the potential association between obstructive sleep apnoea (OSA) and cancer [1–10]. Available studies have reached contradictory conclusions due to limited sample sizes, and poor characterisation of OSA phenotypes or type of malignancies (all types [1–4] or site specific [6–8]). Several hypotheses have been formulated proposing why carcinogenesis can occur in the context of OSA, including older age, sleep deprivation [11, 12] and concomitant obesity [13]. Intermittent hypoxia and sleep fragmentation may play a significant role via alterations in angiogenesis, sympathetic outflow, or modulation of immune function and tumour microenvironment [11, 12]. Gender-specific differences in the association between OSA and cancer prevalence have been...
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关键词翻译
关键词翻译
  • sleep 睡眠
  • apnoea 呼吸暂停
  • debatable 可争论的
  • carcinogenesis 癌形成
  • potential 
  • Cancer 巨蟹座
  • obstructive 阻碍的
  • prevalence 传播
  • hypoxia 氧过少
  • angiogenesis 血管生成