Are indexed values better for defining exercise pulmonary hypertension?
作者: Jason WeatheraldAthénaïs BouclyEdmund LauLaurent GodinasLaurent SavaleXavier JaïsDavid MontaniOlivier SitbonGérald SimonneauMarc HumbertDenis ChemlaPhilippe Hervé
作者单位: 1Dept of Medicine, Division of Respirology, University of Calgary, Calgary, Canada
2Faculté de Médecine, Université Paris-Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, France
3Service de Pneumologie, Assistance Publique-Hôpitaux de Paris, Le Kremlin-Bicêtre, France
4INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis Robinson, France
5Sydney Medical School, University of Sydney, Sydney, Australia
6Dept of Respiratory Medicine, Royal Prince Alfred Hospital, Camperdown, Australia
7Service de Pneumologie, CHU UcL Namur, Yvoir, Belgium
8Service de Physiologie, Assistance Publique-Hôpitaux de Paris, Le Kremlin-Bicetre, France
9Département de Chirurgie Thoracique et Vasculaire et de Transplantation Cardio-Pulmonaire, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France
刊名: European Respiratory Journal, 2017, Vol.50 (3)
来源数据库: European Respiratory Society
DOI: 10.1183/13993003.00240-2017
原始语种摘要: Pulmonary hypertension (PH) is defined by resting mean pulmonary arterial pressure (mPAP) ≥25 mmHg [1]. Patients with pulmonary vascular disease (PVD) or left heart disease (LHD) may demonstrate abnormal haemodynamic responses to exercise even when resting mPAP is normal [2]. After the 4th World Symposium on PH in 2008, exercise PH, defined as mPAP >30 mmHg during exercise, was abandoned due to a lack of supportive evidence and the observation that mPAP frequently exceeds 30 mmHg in healthy individuals who attain high cardiac output (CO) [3, 4]. A disproportionate increase in mPAP relative to CO during exercise, however, reflects either an increase in pulmonary vascular resistance (PVR), as in PVD, or elevated left ventricular filling pressure in LHD. Therefore, attention to the mPAP/CO...
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  • exercise 练习
  • hypertension 高血压
  • pulmonary 肺的
  • defining 定义
  • better 较好的
  • supportive 支援性
  • demonstrated 探明的储量
  • maximal 最大的
  • abnormal 异常的
  • either 任何