Inspiratory muscle function, dynamic hyperinflation and exertional dyspnoea in pulmonary arterial hypertension
作者: Pierantonio LavenezianaMarc HumbertLaurent GodinasBarbara JoureauRoxane MalrinChristian StrausXavier JaïsOlivier SitbonGérald SimonneauThomas SimilowskiGilles Garcia
作者单位: 1Sorbonne Universités, UPMC Univ. Paris 06, UMR_S 1158, Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France
2INSERM, UMR_S 1158, Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France
3AP-HP, Groupe Hospitalier Pitié-Salpêtrière Charles Foix, Service des Explorations Fonctionnelles de la Respiration, de l'Exercice et de la Dyspnée, Paris, France
4AP-HP, Hôpital Universitaire de Bicêtre, Service d'Explorations Fonctionnelles Respiratoires, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU TORINO “Thorax Innovation”, Le Kremlin-Bicêtre, France
5Univ. Paris-Sud 11, Faculté de médecine, Le Kremlin-Bicêtre, France
6INSERM U999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis-Robinson, France
7AP-HP, Hôpital Universitaire de Bicêtre, Service de Pneumologie et Soins Intensifs Thoraciques, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU TORINO “Thorax Innovation”, Le Kremlin-Bicêtre, France
8AP-HP, Groupe Hospitalier Pitié-Salpêtrière Charles Fo
刊名: European Respiratory Journal, 2015, Vol.45 (5), pp.1495-1498
来源数据库: European Respiratory Society
DOI: 10.1183/09031936.00153214
原始语种摘要: Despite a preserved forced expiratory volume in 1 s (FEV1)/vital capacity (VC), patients with idiopathic or heritable pulmonary arterial hypertension (PAH) may dynamically decrease their inspiratory capacity (IC) during cycle exercise ( i.e. dynamic hyperinflation) [1–3] and this could increase exertional dyspnoea [1, 3, 4]. Little information is currently available about whether the reduced IC during cycle exercise is related to respiratory mechanics abnormalities or to impaired inspiratory muscle function (fatigue or weakness). The aim of this study was to evaluate the relationship between inspiratory muscle activity, dynamic changes in IC and the intensity of dyspnoea in PAH patients undergoing incremental symptom-limited cardiopulmonary cycle exercise test (CPET).
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关键词翻译
关键词翻译
  • hyperinflation 过度膨胀
  • dyspnoea 呼吸困难
  • hypertension 高血压
  • inspiratory 吸气的
  • arterial 动脉的
  • muscle 肌肉
  • pulmonary 肺的
  • dynamic 动力学的
  • expiratory 吐气的
  • exercise 练习