NOVEL TRANSETHOSOME CONTAINING GREEN TEA (CAMELLIA SINENSIS L. KUNTZE) LEAF EXTRACT FOR ENHANCED SKIN DELIVERY OF EPIGALLOCATECHIN GALLATE: FORMULATION AND IN VITRO PENETRATION TEST
作者: Effionora AnwarDelly RamadonGhina Desviyanti Ardi
作者单位: 1Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Indonesia. effionora.anwar@farmasi.ui.ac.id
刊名: International Journal of Applied Pharmaceutics, 2018, Vol.10 (1), pp.299-302
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ijap.2018.v10s1.66
原始语种摘要: Objective: This study aimed to formulate a transethosome cream (TEC) to increase skin penetration of epigallocatechin gallate (EGCG) in green tealeaf extract and evaluate their physicochemical characteristics and skin penetration capacity.Methods: Transethosomes were prepared through thin-layer hydration method in three formulations (F1−F3) with different Span 80 and ethanol concentrations.Transethosome morphology was characterized using transmission electron microscopy, particle size, polydispersity (PDI), and zeta potential using a particlesize analyzer and entrapment efficiency (EE). Penetration was tested using an in vitro Franz diffusion cell with female Sprague-Dawley rat skin as themembrane.Results: Transethosome F2 containing green tea extract equivalent to 3% EGCG, 4% Lipoid P30,...
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关键词翻译
关键词翻译
  • increase 增加
  • penetration 穿透
  • efficiency 效率
  • potential 
  • greater 较大
  • concentrations 浓聚物
  • TEC Technical
  • particle 颗粒
  • polydispersity 多分散性
  • ethanol 乙醇