TITANIUM NANOPARTICLES CONJUGATED WITH STREPTOKINASE AS A MODIFIED THROMBOLYTIC AGENT
作者: HAYDER H. ABEDESTABRAQ AR. ALWASITIAMIR T. TAWFEEQ
作者单位: 1Physiology, Chemistry and Pharmacology Department/Veterinary Medicine College/Al-Muthanna University. hayderhussein862@mu.edu.iq
刊名: International Journal of Current Pharmaceutical Research, 2020, pp.18-25
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ijcpr.2020v12i1.36824
原始语种摘要: Objective: Blood clots are the main cause of death worldwide by stroke and myocardial infarction. Streptokinase a thrombolytic agent that is used in the treatment of circulatory disorders. Methods: Titanium Nanoparticles was supplied from Changsha Santech Co. Its characterized were studied using (FT-IR, XRD, AFM, FE-SEM). Streptokinase at concentration 0.1 mg/ml was conjugated with Titanium nanoparticles using PH equal to 5.2 with continuous stirring. Formation of Streptokinase loading Titanium nanoparticles confirmed using FT-IR, Ninhydrine’s test and Bradford protein assay. Physicochemical Properties were studied in vitro. Thrombolytic activity in vitro was determined using d–dimer indicator and weight of blood clot after treatment as indicators of thrombolytic activity. Results:...
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关键词翻译
关键词翻译
  • thrombolytic 溶解血栓的
  • streptokinase 链激酶
  • infarction 梗塞
  • myocardial 心肌的
  • dimer 二聚物
  • activity 活度
  • loading 加负载
  • worldwide 世界的
  • studied 学习
  • stroke 笔划