FORMULATION OF A CREAM CONTAINING ETHOSOMAL GREEN TEA (CAMELLIA SINENSIS L. KUNTZE) LEAF EXTRACTS FOR IMPROVED DERMAL PENETRATION
作者: Effionora AnwarJeanetha IneesDelly Ramadon
作者单位: 1Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia.. effionora.anwar@farmasi.ui.ac.id
刊名: International Journal of Applied Pharmaceutics, 2018, Vol.10 (1), pp.221-224
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ijap.2018.v10s1.49
原始语种摘要: Objective: This study aimed to formulate the epigallocatechin gallate (EGCG) from green tea into ethosomes and measure the resulting increases inskin penetration using a rat model.Methods: Ethosomes were formulated using ethanol concentrations of 25% (F1), 30% (F2), and 35% (F3), and those with favorable characteristicswere then incorporated into a cream for the determination of penetration into Franz diffusion cells.Results: We showed that the formulation F3 had the best spherical morphology, a Z-average value of 73.01 nm, a polydispersity index of 0.26, azeta potential of −47.77±3.93 mV, and the highest percentage of drug entrapment (49.46%±0.62%) compared with the other formulas. The totalcumulative EGCG penetration from the resulting ethosomal cream was 905.75±49.47 μg/cm2, whereas...
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关键词翻译
关键词翻译
  • penetration 穿透
  • formulate 公式化
  • resulting 引起的
  • containing 包含的
  • TEA TRANS EUROPEAN AIRWAYS
  • morphology 形态学
  • formulation 配方
  • polydispersity 多分散性
  • determination 测定
  • gallate 没食子酸盐